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Top Performing ETFs of 2021: A Comprehensive Guide to Smart Investment Choices

May. 21,2025

Discover the top-performing ETFs of 2021, including market leaders like SPY, QQQ, VOO, and innovative funds like ARKG. Learn about their asset fokus, performance, and suitability for diversified investment strategies. This comprehensive guide helps investors understand key options to boost portfolio growth with low costs and targeted exposure, making it an essential resource for those aiming to optimize their investment returns in the evolving market landscape of 2021.

Top Performing ETFs of 2021: A Comprehensive Guide to Smart Investment Choices

Leading Exchange-Traded Funds (ETFs) That Dominated 2021

In 2021, Exchange-Traded Funds (ETFs) continued to grow in popularity among investors of all levels, especially due to their ease of access, cost-effectiveness, and diversification benefits. These investment vehicles offer an excellent way for both beginners and seasoned investors to gain exposure to various sectors and market strategies without the complexities associated with direct stock picking. As the year closed, certain ETFs stood out due to their impressive returns, liquidity, and strategic focus, shaping the investment landscape in 2021. This detailed review highlights the top ETFs of 2021, exploring their performance, expense ratios, underlying assets, and strategic importance in a diversified portfolio.

SPDR S&P 500 ETF (SPY): The Benchmark of Large-Cap U.S. Stocks
The SPDR S&P 500 ETF, commonly referred to as SPY, remains an iconic ETF and a cornerstone for many investment portfolios. With assets totaling over $360 billion, SPY is recognized for its unparalleled liquidity—trading more than 74 million shares daily—making it one of the most traded ETFs worldwide. Its low expense ratio of 0.09% ensures that investors incur minimal costs while tracking the performance of the S&P 500 index, which comprises the top 500 large-cap U.S. companies. This ETF provides broad market exposure, capturing the performance of industry leaders across multiple sectors. Due to its stability, liquidity, and efficiency, SPY is frequently used as a benchmark for U.S. stock market performance and as a core holding in diversified portfolios.

Invesco QQQ Trust (QQQ): Tech Sector’s Leading Indicator
The Invesco QQQ Trust stands out as an ETF that offers concentrated exposure to the Nasdaq-100 Index, which includes 100 of the largest non-financial companies listed on the Nasdaq Stock Market. This ETF is heavily weighted towards technology giants such as Apple, Microsoft, Amazon, and other innovative firms that have driven market gains in recent years. In 2020, QQQ experienced a remarkable growth rate of 48.4%, driven by the explosive expansion of the tech sector amidst the COVID-19 pandemic and digital transformation trends. With an expense ratio of just 0.2%, QQQ remains a preferred choice for investors seeking targeted exposure to the fastest-growing technology companies, often leading market performance during bullish years.

Vanguard S&P 500 ETF (VOO): Diversification with Low Cost
Launched in 2010, the Vanguard S&P 500 ETF (VOO) is known for its broad exposure to large-cap U.S. stocks, mirroring the performance of the S&P 500 Index. Managing hundreds of billions of dollars in assets, VOO offers investors an affordable, diversified investment option with an extremely low expense ratio of only 0.03%. Its performance in 2020 was notably strong, delivering an 18.3% return that aligned with the overall market rally. VOO is favored for its cost-efficiency and stability, making it an ideal foundation for long-term retirement and wealth-building portfolios, especially for investors seeking low-cost exposure to the top American companies across multiple sectors.

ARK Genomic Revolution ETF (ARKG): Investing in Future Technologies
For investors interested in innovative, high-growth sectors, the ARK Genomic Revolution ETF (ARKG) offers a compelling opportunity. Managed actively by the renowned investor Cathie Wood, ARKG invests in cutting-edge biotech, healthcare, and genomics companies involved in gene editing, stem cell research, and agriculture biology. These high-potential yet high-risk assets have the potential to revolutionize healthcare and agriculture in the coming decades. Although ARKG comes with a higher annual expense ratio of 0.75%, it has delivered impressive long-term returns, with a cumulative gain of over 40.3% over the past five years. This ETF caters to aggressive investors seeking exposure to disruptive innovations that could shape the future of medicine and biotech industries.