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Comprehensive Review of the 2021 Mercedes-Benz E 350 Sedan: Features, Performance, and Safety

May. 31,2025

The 2021 Mercedes-Benz E 350 stands out as a luxury sedan that combines exceptional performance, innovative safety features, and high-end comfort. With its powerful engine, advanced driver assistance, and premium interior amenities, this vehicle offers a refined driving experience suitable for both everyday use and special occasions. Discover why the E 350 remains a top choice in the luxury sedan segment, blending elegance, technology, and safety in perfect harmony.

Comprehensive Review of the 2021 Mercedes-Benz E 350 Sedan: Features, Performance, and Safety

In-Depth Overview of the 2021 Mercedes-Benz E 350

The 2021 Mercedes-Benz E 350 continues to uphold its reputation as a luxury sedan that seamlessly combines elegance, advanced technology, and exceptional performance. Designed for discerning drivers who prioritize safety, comfort, and cutting-edge features, this model stands out in the premium vehicle segment. Whether you're a luxury car enthusiast or a daily commuter seeking sophisticated amenities, the E 350 offers a compelling package packed with innovations and top-tier performance attributes. Let’s explore the detailed features that make the 2021 Mercedes-Benz E 350 a formidable contender in its class.

From its powerful yet efficient engine to its advanced safety systems and luxurious interior, this sedan caters to those who seek a refined driving experience. Here, we delve into the key aspects that set this vehicle apart from other models in the luxury sedan segment.

Robust Performance and Dynamic Handling


The heart of the 2021 Mercedes-Benz E 350 is its sophisticated powertrain. Equipped with a 2.0-liter turbocharged four-cylinder engine, this sedan delivers an impressive 255 horsepower along with 273 pound-feet of torque. The turbocharged system ensures a balanced blend of power and fuel efficiency, making it an ideal choice for both city driving and highway cruising. The engine’s design emphasizes smooth power delivery while maintaining optimal fuel economy, which is essential for daily commuting and long-distance travel.

The performance is complemented by a nine-speed automatic transmission that guarantees seamless gear changes and responsive handling. This transmission system adapts intelligently to driving conditions, ensuring that acceleration feels natural and effortless. Drivers can choose between four distinct driving modes—ECO for maximum efficiency, Comfort for everyday smoothness, Sport for enhanced aggressiveness, and Sport+ for the ultimate dynamic experience. Additionally, a customizable fifth mode allows drivers to tailor the vehicle’s characteristics according to personal preferences. The chassis and suspension setup are tuned for exceptional ride comfort and precise steering, making the E 350 agile yet refined.

Innovative Safety and Driver Assistance Technologies


Safety has always been a cornerstone of Mercedes-Benz’s vehicle lineup, and the 2021 E 350 exemplifies this commitment through a comprehensive suite of safety features. One of the standout technologies is the Car-to-X Communication system, which is a proactive safety feature that communicates with other vehicles and infrastructure to warn of upcoming hazards or traffic conditions. This networked communication helps reduce the risk of collisions and enhances overall driving safety.

In case of emergencies, the E 350 automatically connects to Mercedes-Benz Emergency Services, providing rapid assistance when needed. The Attention Assist system continuously monitors driver alertness levels through steering and pedal inputs, issuing alerts if signs of drowsiness or fatigue are detected—thus preventing potential accidents caused by driver inattentiveness.

Active Brake Assist, equipped with radar sensors, plays a vital role in collision avoidance. It detects potential obstacles, such as slower-moving vehicles or pedestrians, and warns the driver. If necessary, the system can automatically engage braking to mitigate or even prevent accidents, setting a new standard for active safety systems in luxury sedans.

Cutting-Edge Infotainment and Connectivity


The 2021 Mercedes-Benz E 350 features a state-of-the-art infotainment system designed to keep the driver connected and entertained. The centerpiece is a 12.3-inch high-resolution touchscreen multimedia display that offers intuitive control over navigation, audio, phone connectivity, and vehicle settings. The interface is user-friendly, with menu layouts that are easy to navigate while driving.

The system supports voice commands, allowing hands-free operation for calls, navigation, and media control, thereby increasing safety and convenience. The steering wheel is equipped with touch-sensitive buttons for quick access to Bluetooth, audio controls, and cruise control functions. In addition, a second 12.3-inch display in front of the driver provides critical information such as current speed, driver-assistance status, and vehicle alerts, all presented with clear visuals and high detail to minimize distraction.

This advanced infotainment setup enhances the driving experience, making every journey both enjoyable and connected.

Luxurious Comfort and Convenience Features


The interior of the E 350 is designed to provide maximum comfort, especially during long drives. The seats are memory-enabled, permitting drivers the convenience of saving preferred seating positions, including adjustments for the steering column and side mirrors. These features are essential for multiple drivers sharing the vehicle, offering a quick and seamless way to personalize the driving position.

The power-adjustable front seats come with eight massage programs, allowing occupants to relax after a long day or during extended trips. The dual-zone climate control system enables both driver and front passenger to set their preferred temperatures independently, ensuring optimal comfort for everyone onboard. Premium materials such as high-quality leather upholstery and sophisticated trim accents elevate the interior aesthetic, contributing to a high-end ambiance.

Additional comfort features include ambient LED lighting, a premium sound system, and keyless entry and ignition. These amenities collectively create an environment of luxury and convenience, making every drive pleasurable. The spacious cabin, combined with thoughtful design and ergonomic placement of controls, ensures that both driver and passengers enjoy a serene, refined experience.

Summary: Why the 2021 Mercedes-Benz E 350 Is a Leading Choice


The 2021 Mercedes-Benz E 350 encapsulates the essence of luxury, performance, and safety. Its powerful yet efficient engine delivers a dynamic driving experience, while advanced safety features provide peace of mind on every journey. The intuitive infotainment systems ensure connectivity and entertainment, and the plush interior offers unmatched comfort. All these aspects make the E 350 an attractive option for those seeking a premium sedan that combines elegance with practicality. Whether for daily commuting, long road trips, or status display, the E 350 is engineered to impress and deliver consistent high performance.